NEXTGEN Cassava PhD student Roberto Lozano recently attended a two-week course on Statistical Methods for Functional Genomics at Cold Spring Harbor Laboratory (CSHL), and he reports on it here:
CSHL is considered among the leading research institutions in the world in molecular biology and genetics. Not only because of its history (considerable long list of noble laureates) but also for the current research taking place there.
Part of my research as a graduate student is focused on using high-throughput genomic data to identify functional regions across the cassava genome and try to use this information to improve Cassava GS-assisted breeding. Some of the high-throughput genomic data will come from transcriptome sequencing, chromatin footprinting and methylation profiling analysis.
High-throughput sequencing has become a major technique in biological research. However analyzing big data sets, products of these technologies, carries some challenges that are not always properly tackled. These kinds of errors can threaten the biological inferences that are made. All the techniques that I planned on using for my research carry some unique difficulties and sometimes complex statistical principles underlying their analysis methods. This course tackled all those techniques, and the instructors and speakers have wide experience working with that kind of data. That’s what initially caught my attention to apply for this course.
After taking it I have to admit that it was as good as it could get. All the instructors were great; each of them leads their own top-notch research group, and they were really helpful and resourceful. The invited speakers were great as well, showing some of the latest techniques and applications of next-gen sequencing. The attendees came from a wide variety of fields and from all around the world, working in both Academia and private companies, and the wide variety of their study fields (cancer, neurobiology, plant genomics, immunology and more) really assured lots of interesting discussions. Finally I had to mention that even the location of the Cold Spring Harbor Labs was something else, a beautiful environment that let people focus on their research.